HPS5 Polyclonal antibody

HPS5 Polyclonal Antibody for WB, IHC, IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, ELISA

Conjugate

Unconjugated

Cat no : 13901-1-AP

Synonyms

KIAA1017, Hermansky-Pudlak syndrome 5 protein, Hermansky Pudlak syndrome 5, BLOC-2 complex member HPS5, Alpha-integrin-binding protein 63


☆対象製品が30%オフ!組換えタンパク質&免染用試薬 >>> キャンペーン実施中!


Tested Applications

Positive WB detected inmouse liver tissue, mouse spleen tissue
Positive IHC detected inhuman placenta tissue, human heart tissue, human lung tissue, human skin tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inMCF-7 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2400
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)/ICCIF/ICC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 6 publications below

Product Information

13901-1-AP targets HPS5 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen HPS5 fusion protein Ag4867 相同性解析による交差性が予測される生物種
Full Name Hermansky-Pudlak syndrome 5
Calculated molecular weight 1129 aa, 127 kDa
Observed molecular weight 135-141 kDa
GenBank accession numberBC033640
Gene symbol HPS5
Gene ID (NCBI) 11234
RRIDAB_2120685
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Hermansky-Pudlak syndrome 5 protein (HPS-5), also named Ruby-eye protein 2 homolog (Ru2), plays a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5.

Protocols

Product Specific Protocols
WB protocol for HPS5 antibody 13901-1-APDownload protocol
IHC protocol for HPS5 antibody 13901-1-APDownload protocol
IF protocol for HPS5 antibody 13901-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Blood

vWF maturation and release are controlled by two regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2.

Authors - Anish Vaibhav Sharda
humanWB

Am J Hum Genet

A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9.

Authors - Cullinane Andrew R AR
humanWB

J Invest Dermatol

Clinical, molecular, and cellular features of non-Puerto Rican Hermansky-Pudlak syndrome patients of Hispanic descent.

Authors - Carmona-Rivera Carmelo C
humanWB

Pigment Cell Melanoma Res

A BLOC-1 mutation screen reveals a novel BLOC1S3 mutation in Hermansky-Pudlak Syndrome type 8.

Authors - Cullinane Andrew R AR
humanWB

PLoS One

Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5.

Authors - Joshi Stephen
humanWB

Front Genet

Oculocutaneous albinism and bleeding diathesis due to a novel deletion in the HPS3 gene

Authors - Dina Marek-Yagel