CoraLite®594-conjugated IBA1 Monoclonal antibody
IBA1 Monoclonal Antibody for IF
Host / Isotype
Mouse / IgG1
Reactivity
Human and More (1)
Applications
IF
Conjugate
CoraLite® Plus 594 Fluorescent Dye
CloneNo.
1C6A10
Cat no : CL594-66827
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
IF | See 1 publications below |
Product Information
CL594-66827 targets IBA1 in IF applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Cited Reactivity | mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | IBA1 fusion protein Ag28236 相同性解析による交差性が予測される生物種 |
Full Name | allograft inflammatory factor 1 |
Calculated molecular weight | 17 kDa |
GenBank accession number | BC009474 |
Gene symbol | IBA1 |
Gene ID (NCBI) | 199 |
Conjugate | CoraLite® Plus 594 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 593 nm / 614 nm |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.
Publications
Species | Application | Title |
---|---|---|
Brain Behav Immun Extracellular RNAs-TLR3 signaling contributes to cognitive decline in a mouse model of postoperative cognitive dysfunction. |