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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human ICOS/CD278 Rabbit Recombinant Antibody, PBS Only

ICOS/CD278 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241770G11

Cat no : 98214-1-PBS

Synonyms

ICOS, CVID1, CD278, AILIM, Activation-inducible lymphocyte immunomediatory molecule

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR)

    FC experiment of human PBMCs using 98214-1-RR (same clone as 98214-1-PBS)

    1x10^6 untreated or PHA treated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were not fixed. This data was developed using the same antibody clone with 98214-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR)

    FC experiment of human PBMCs using 98214-1-RR (same clone as 98214-1-PBS)

    1x10^6 PHA treated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human ICOS/CD278 Rabbit Recombinant Antibody (98214-1-RR, Clone: 241770G11) (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98214-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

98214-1-PBS targets ICOS/CD278 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name inducible T-cell co-stimulator
Calculated molecular weight 199 aa, 23 kDa
GenBank accession numberBC028210
Gene symbol ICOS
Gene ID (NCBI) 29851
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Inducible T cell co-stimulator (ICOS) is related to the CD28 superfamily and is highly expressed on activated T cells as well as regulatory T cells and is crucial for the survival and function of T cells, Th2 cell differentiation, and lung inflammatory responses. Binding ICOS to ICOS-ligand (ICOS-L) activates a cascade of intracellular signaling molecules that prevent apoptosis and lead to the production of cytokines such as IL-4 and IL-13.