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IDE Monoclonal antibody, PBS Only

IDE Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3E10G1

Cat no : 67106-1-PBS

Synonyms

Abeta degrading protease, FLJ35968, IDE, INSULYSIN


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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67106-1-PBS targets IDE in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Reactivity Human, Mouse, Rat
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen IDE fusion protein Ag17161 相同性解析による交差性が予測される生物種
Full Name Abeta degrading protease
Calculated molecular weight 1019 aa, 118 kDa
Observed molecular weight 100-120 kDa
GenBank accession numberBC096336
Gene symbol IDE
Gene ID (NCBI) 3416
RRIDAB_2882410
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

IDE(INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid(PMID:9830016). The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism(PMID:12507914). It can exsit as a homodimer and form higher oligomers(PMID:17613531).