Validation Data Gallery
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Tested Applications
| Positive WB detected in | Jurkat cells, K-562 cell, mouse liver tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 2 publications below |
| WB | See 12 publications below |
| IF | See 1 publications below |
| IP | See 1 publications below |
Product Information
13083-1-AP targets IFNAR1 in WB, IF, IP, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IFNAR1 fusion protein Ag3739 相同性解析による交差性が予測される生物種 |
| Full Name | interferon (alpha, beta and omega) receptor 1 |
| Calculated molecular weight | 557 aa, 64 kDa |
| Observed molecular weight | 64 kDa |
| GenBank accession number | BC021825 |
| Gene Symbol | IFNAR1 |
| Gene ID (NCBI) | 3454 |
| RRID | AB_2122626 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P17181 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Interferon alpha and beta receptor subunit 1 (IFNAR1) is a type I membrane protein that associates with IFNAR2 to form the receptor for type I interferons, including interferons-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2, and then increase transcription of the IFN-induced genes whose products exert antiviral, immunomodulatory, and antiproliferative effects.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for IFNAR1 antibody 13083-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
EMBO Rep Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA | ||
Elife The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress.
| ||
J Virol African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway | ||
Cell Rep TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response. |