Validation Data Gallery
Filter:
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
84372-5-PBS targets IKKA in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | IKKA fusion protein Ag26573 相同性解析による交差性が予測される生物種 |
| Full Name | conserved helix-loop-helix ubiquitous kinase |
| Calculated molecular weight | 85 kDa |
| GenBank accession number | NM_001278 |
| Gene Symbol | IKK Alpha |
| Gene ID (NCBI) | 1147 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | O15111 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
NF‐κB is regulated by phosphorylation of one of its cytoplasmic inhibitors, IκB, mediated by IκB kinases (IKK), allowing NF‐κB nuclear translocation and transcriptional activation. IKKα‐IKKβ heterodimer complexes regulate the DNA binding proteins implicated in the canonical NF‐κB pathway, including p50‐p65, while IKKα‐homodimers regulate p52‐RELB dimers implicated in the alternative NF‐κB pathway. (PMID: 34187082)