IL-19 Monoclonal antibody, PBS Only
IL-19 Monoclonal Antibody for IHC, IF/ICC, IF-P, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human
Applications
IHC, IF/ICC, IF-P, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
8H10H8
Cat no : 60278-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60278-1-PBS targets IL-19 in IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | IL-19 fusion protein Ag18887 相同性解析による交差性が予測される生物種 |
Full Name | interleukin 19 |
Calculated molecular weight | 177 aa, 20 kDa |
GenBank accession number | BC153127 |
Gene symbol | IL-19 |
Gene ID (NCBI) | 29949 |
RRID | AB_2881397 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.