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IL-19 Monoclonal antibody, PBS Only

IL-19 Monoclonal Antibody for IHC, IF/ICC, IF-P, Indirect ELISA
Cat No. 60278-1-PBS
Clone No.8H10H8

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

IHC, IF/ICC, IF-P, Indirect ELISA

IL19, interleukin19, interleukin 19, IL 19, IL 10C

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration:  100 μg, 1mg/ml
100 μg, 1mg/ml

¥167,000/ 100 μg

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

60278-1-PBS targets IL-19 in IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen IL-19 fusion protein Ag18887 相同性解析による交差性が予測される生物種
Full Name interleukin 19
Calculated molecular weight 177 aa, 20 kDa
GenBank accession numberBC153127
Gene Symbol IL-19
Gene ID (NCBI) 29949
RRIDAB_2881397
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ9UHD0
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.

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