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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

IL-31 Polyclonal antibody, PBS Only

IL-31 Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 22859-1-PBS

Synonyms

Validation Data Gallery

Filter:
  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using IL-31 Polyclonal antibody (22859-1-AP)

    IHC staining of human tonsillitis using 22859-1-AP (same clone as 22859-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22859-1-AP (IL31 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22859-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using IL-31 Polyclonal antibody (22859-1-AP)

    IHC staining of human tonsillitis using 22859-1-AP (same clone as 22859-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22859-1-AP (IL31 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22859-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using IL-31 Polyclonal antibody (22859-1-AP)

    IHC staining of human tonsillitis using 22859-1-AP (same clone as 22859-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22859-1-AP (IL31 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22859-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human small intestine tissue using IL-31 Polyclonal antibody (22859-1-AP)

    IHC staining of human small intestine using 22859-1-AP (same clone as 22859-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 22859-1-AP (IL31 Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 22859-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human small intestine tissue using IL-31 Polyclonal antibody (22859-1-AP)

    IHC staining of human small intestine using 22859-1-AP (same clone as 22859-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 22859-1-AP (IL31 Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 22859-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using IL-31 Polyclonal antibody (22859-1-AP)

    IHC staining of human tonsillitis using 22859-1-AP (same clone as 22859-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 22859-1-AP (IL31 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22859-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

22859-1-PBS targets IL-31 in IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IL-31 fusion protein Ag18848 相同性解析による交差性が予測される生物種
Full Name interleukin 31
Calculated molecular weight 164 aa, 18 kDa
GenBank accession numberBC132998
Gene symbol IL-31
Gene ID (NCBI) 386653
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

IL-31 mRNA encodes a 164-aa precursor and a predicted 141-aa mature polypeptide, displaying an apparent molecular mass of 24 kDa in its glycosylated form. IL31 is a newly discovered four-helix bundle cytokine and expressed by several types of cells under both normal and disease state, such as activated CD4+T cells, mast cells, monocytes, macrophages, immature and mature monocyte-derived dendritic cells and so on. IL-31 signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31Rα) and the oncostatin M receptor (OSMR). IL-31 plays a predominant function in the mediation of inflammatory and lymphoma-associated itch. Increased IL-31 expression has been detected in inflamed tissues from patients with atopic dermatitis, bowel diseases, allergic asthma and rhinitis.