IL-21R Polyclonal antibody

IL-21R Polyclonal Antibody for WB, IHC, IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, ELISA

Conjugate

Unconjugated

Cat no : 10533-1-AP

Synonyms

IL21R, interleukin 21 receptor, IL-21 receptor, IL 21R, IL 21 receptor


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Tested Applications

Positive WB detected inCOLO 320 cells, K-562 cells, mouse thymus tissue, Raji cells, rat thymus tissue
Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inCOLO 320 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:5000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)/ICCIF/ICC : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10533-1-AP targets IL-21R in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IL-21R fusion protein Ag0762 相同性解析による交差性が予測される生物種
Full Name interleukin 21 receptor
Calculated molecular weight 59 kDa
Observed molecular weight 68-70 kDa
GenBank accession numberBC004348
Gene symbol IL-21R
Gene ID (NCBI) 50615
RRIDAB_2124107
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

IL21R, a receptor for interleukin-21, belongs to the type I cytokine receptor family. IL21R has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3.

Protocols

Product Specific Protocols
WB protocol for IL-21R antibody 10533-1-APDownload protocol
IHC protocol for IL-21R antibody 10533-1-APDownload protocol
IF protocol for IL-21R antibody 10533-1-APDownload protocol
FC protocol for IL-21R antibody 10533-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

J Immunother Cancer

Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma.

Authors - Yao Yao
humanWB,IF

Stem Cells Int

Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells.

Authors - Bruna Cristina Falavinha
ratWB,IF

Int Immunopharmacol

Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis

Authors - Xue Zhang