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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

ITM2C Polyclonal antibody, PBS Only

ITM2C Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13601-1-PBS

Synonyms

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human colon tissue using ITM2C Polyclonal antibody (13601-1-AP)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using ITM2C Polyclonal antibody (13601-1-AP)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

13601-1-PBS targets ITM2C in IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ITM2C fusion protein Ag3876 相同性解析による交差性が予測される生物種
Full Name integral membrane protein 2C
Calculated molecular weight230aa,26 kDa; 267aa,30 kDa
Observed molecular weight 30 kDa
GenBank accession numberBC025742
Gene symbol ITM2C
Gene ID (NCBI) 81618
RRIDAB_2877960
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.