Integrin beta-6 Polyclonal antibody

Integrin beta-6 Polyclonal Antibody for WB, IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human, Mouse and More (1)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 28378-1-AP

Synonyms

Integrin beta 6, Integrin beta-6, integrin, beta 6, ITGB6


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Tested Applications

Positive WB detected inA431 cells
Positive IHC detected inmouse lung tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

28378-1-AP targets Integrin beta-6 in WB, IHC, ELISA applications and shows reactivity with Human, Mouse samples.

Tested Reactivity Human, Mouse
Cited Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Integrin beta-6 fusion protein Ag29002 相同性解析による交差性が予測される生物種
Full Name integrin, beta 6
Calculated molecular weight 788 aa, 86 kDa
Observed molecular weight97 kDa
GenBank accession numberBC121178
Gene symbol Integrin beta 6
Gene ID (NCBI) 3694
RRIDAB_2918157
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ITGB6 belongs to the integrin beta chain family. ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

Protocols

Product Specific Protocols
WB protocol for Integrin beta-6 antibody 28378-1-APDownload protocol
IHC protocol for Integrin beta-6 antibody 28378-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Front Oncol

The association and clinicopathological significance of Integrin alphavbeta6 and Rac1 expression in gastric carcinoma

Authors - Junjian Yu
humanWB,IHC

Transl Lung Cancer Res

Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway

Authors - Xiang Feng