Kir6.2 Polyclonal antibody
Kir6.2 Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, ELISA
Conjugate
Unconjugated
Cat no : 16920-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | rat heart tissue, HepG2 cells, human heart tissue, rat skeletal muscle tissue |
Recommended dilution
Application | Dilution |
---|---|
Western Blot (WB) | WB : 1:200-1:1000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
WB | See 1 publications below |
Product Information
16920-1-AP targets Kir6.2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Cited Reactivity | rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Kir6.2 fusion protein Ag10262 相同性解析による交差性が予測される生物種 |
Full Name | potassium inwardly-rectifying channel, subfamily J, member 11 |
Calculated molecular weight | 390 aa, 44 kDa |
Observed molecular weight | 48 kDa |
GenBank accession number | BC064497 |
Gene symbol | Kir6.2 |
Gene ID (NCBI) | 3767 |
RRID | AB_2130461 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Kir6.2 (also known as BIR or IKATP), encoded by the KCNJ11 gene, is the pore-forming unit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel. Kir6.2 is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel. The KCNJ11 gene is located at 11p15.1 and has no intron. Mutations in KCNJ11 are a cause of familial PHHI, an autosomal recessive disorder characterized by unregulated ins secretion. Defects in KCNJ11 may also contribute to autosomal dominant non-ins-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM).
Protocols
Product Specific Protocols | |
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WB protocol for Kir6.2 antibody 16920-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
Publications
Species | Application | Title |
---|---|---|
Life Sci KATP channels as ROS-dependent modulator of neurotransmitter release at the neuromuscular junctions | ||
Sci Rep Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells |