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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibody

KIM-1/HAVCR1 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

242001E8

Cat no : 98238-1-RR

Synonyms

HAVCR1, KIM-1, TIM-1, KIM1, HAVcr-1

Validation Data Gallery

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  • Flow cytometry (FC) experiment of HuH-7 cells using Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibod (98238-1-RR)

    FC experiment of HuH-7 using 98238-1-RR

    1x10^6 HuH-7 cells (left) or 293-T cells (right) were surface stained with 0.25 ug Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibody (98238-1-RR, Clone: 242001E8) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • Affinity and Kinetic Characterization of 98238-1-RR

    Affinity and Kinetic Characterization of 98238-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98238-1-RR against Human KIM-1/HAVCR1 were performed. The affinity constant is 0.366 nM.

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Tested Applications

Positive FC detected inHuH-7 cells

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98238-1-RR targets KIM-1/HAVCR1 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name hepatitis A virus cellular receptor 1
Calculated molecular weight39kDa
GenBank accession numberNM_001173393.3
Gene symbol HAVCR1
Gene ID (NCBI) 26762
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

Background Information

Kidney injury molecule 1 (KIM-1), also known as Hepatitis A virus cellular receptor 1 (HAVCR1), CD365, or T-cell immunoglobulin and mucin domain 1 (TIM-1), is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. KIM-1 acts as a membrane receptor for hepatitis A virus (HAV) (PMID: 9658108; 8861957). KIM-1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). KIM-1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that KIM-1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).

Protocols

Product Specific Protocols
FC protocol for KIM-1/HAVCR1 antibody 98238-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols