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Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
85168-1-PBS targets KIR2DL1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Recombinant protein 相同性解析による交差性が予測される生物種 |
| Full Name | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 |
| Calculated molecular weight | 39 kDa |
| Observed molecular weight | 45 kDa |
| GenBank accession number | BC069344 |
| Gene Symbol | KIR2DL1 |
| Gene ID (NCBI) | 3802 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | P43626 |
| Storage Buffer | PBS only , pH 7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1, also known as CD158A and NKAT1) is an inhibitory receptor of NK cells, with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling (PMID: 18604210). The effector function of NK cells expressing KIR2DL1 or KIR2DS1 is highly influenced by genetic variability and is calibrated by co-expression of additional NK receptors and cognate HLA-C2 ligands (PMID: 31024561).