LAG-3 Recombinant antibody, PBS Only
LAG-3 Recombinant Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human, Mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1F14
Cat no : 80867-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
Sample-dependent, check data in validation data gallery |
Product Information
80867-1-PBS targets LAG-3 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
Tested Reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | fusion protein 相同性解析による交差性が予測される生物種 |
Full Name | lymphocyte-activation gene 3 |
Calculated molecular weight | 57 kDa |
Observed molecular weight | 60 kDa |
GenBank accession number | NM_002286 |
Gene symbol | LAG3 |
Gene ID (NCBI) | 3902 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)