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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

LAIR1 Recombinant antibody, PBS Only

LAIR1 Recombinant Antibody for IHC, IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241805C2

Cat no : 84677-4-PBS

Synonyms

Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, LAIR 1, hLAIR1, CD305

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using LAIR1 Recombinant antibody (84677-4-RR)

    IHC staining of human tonsillitis using 84677-4-RR (same clone as 84677-4-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 84677-4-RR (LAIR1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84677-4-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using LAIR1 Recombinant antibody (84677-4-RR)

    IHC staining of human tonsillitis using 84677-4-RR (same clone as 84677-4-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 84677-4-RR (LAIR1 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84677-4-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of THP-1 cells using LAIR1 Recombinant antibody (84677-4-RR)

    IF Staining of THP-1 using 84677-4-RR (same clone as 84677-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using LAIR1 antibody (84677-4-RR, Clone: 241805C2 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84677-4-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84677-4-PBS targets LAIR1 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name leukocyte-associated immunoglobulin-like receptor 1
Calculated molecular weight 287 aa, 31 kDa
GenBank accession numberBC027899
Gene symbol LAIR1
Gene ID (NCBI) 3903
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).