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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

LRP4 Polyclonal antibody

LRP4 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 24434-1-AP

Synonyms

KIAA0816, LRP 4, LRP10, LRP4, MEGF7

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using LRP4 Polyclonal antibody (24434-1-AP)

    WB analysis using 24434-1-AP

    Mouse brain tissue was subjected to SDS PAGE followed by western blot with 24434-1-AP (LRP4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Tested Applications

Positive WB detected inmouse brain tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

24434-1-AP targets LRP4 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LRP4 fusion protein Ag19487 相同性解析による交差性が予測される生物種
Full Name low density lipoprotein receptor-related protein 4
Calculated molecular weight 1905 aa, 212 kDa
Observed molecular weight240 kDa
GenBank accession numberBC136667
Gene symbol LRP4
Gene ID (NCBI) 4038
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).

Protocols

Product Specific Protocols
WB protocol for LRP4 antibody 24434-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols