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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

LRRC8C Monoclonal antibody, PBS Only

LRRC8C Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4A6A4

Cat no : 68323-1-PBS

Synonyms

AD158, DKFZp586J1119, FAD158, LRRC8C

Validation Data Gallery

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  • Western Blot (WB) analysis of U2OS cells using LRRC8C Monoclonal antibody (68323-1-Ig)

    WB analysis of U2OS using 68323-1-Ig (same clone as 68323-1-PBS)

    U2OS cells were subjected to SDS PAGE followed by western blot with 68323-1-Ig (LRRC8C antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using LRRC8C Monoclonal antibody (68323-1-Ig)

    WB analysis using 68323-1-Ig (same clone as 68323-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68323-1-Ig (LRRC8C antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using LRRC8C Monoclonal antibody (68323-1-Ig)

    IF Staining of HepG2 using 68323-1-Ig (same clone as 68323-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LRRC8C antibody (68323-1-Ig, Clone: 4A6A4 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68323-1-PBS targets LRRC8C in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen LRRC8C fusion protein Ag17001 相同性解析による交差性が予測される生物種
Full Name leucine rich repeat containing 8 family, member C
Calculated molecular weight 803 aa, 92 kDa
Observed molecular weight105 kDa
GenBank accession numberBC113973
Gene symbol LRRC8C
Gene ID (NCBI) 84230
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

LRRC8C (Leucine-rich repeat-containing protein 8C), also known as AD158, is a non-essential component of the volume-regulated anion channel (VRAC, also known as VSOAC channel), which is required to maintain a constant cell volume in response to extracellular or intracellular permeability changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PMID:24790029; 26824658; 28193731).