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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

LTBP2 Polyclonal antibody

LTBP2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28824-1-AP

Synonyms

C14orf141, LTBP 2, LTBP2, LTBP3, MSTP031

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using LTBP2 Polyclonal antibody (28824-1-AP)

    WB analysis using 28824-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 28824-1-AP (LTBP2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Tested Applications

Positive WB detected inhuman urine sample

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

28824-1-AP targets LTBP2 in WB, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LTBP2 fusion protein Ag29737 相同性解析による交差性が予測される生物種
Full Name latent transforming growth factor beta binding protein 2
Calculated molecular weight 1821 aa, 195 kDa
Observed molecular weight 260 kDa
GenBank accession numberBC078659
Gene symbol LTBP2
Gene ID (NCBI) 4053
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

LTBP2, an extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-β binding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma (PMID: 20179738 ) . LTBP2 is a biomarker of heart failure. LTBP2 has a molecular weight of 260 kDa (PMID: 20878956), and even larger molecular weights of 290 and 310 kDa were detected in tissue extracts. (PMID: 8524260)

Protocols

Product Specific Protocols
WB protocol for LTBP2 antibody 28824-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols