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Conjugate
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Conjugate
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Conjugate
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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

LTBP2 Recombinant antibody, PBS Only

LTBP2 Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241911C7

Cat no : 84574-4-PBS

Synonyms

LTBP3, C14orf141, 241911C7, LTBP-2, LTBP 2

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using LTBP2 Recombinant antibody (84574-4-RR)

    WB analysis using 84574-4-RR (same clone as 84574-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84574-4-RR (LTBP2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84574-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84574-4-RR

    Affinity and Kinetic Characterization of 84574-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84574-4-RR against Human LTBP2 were performed. The affinity constant is 0.779 nM.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84574-4-PBS targets LTBP2 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen LTBP2 fusion protein Ag29720 相同性解析による交差性が予測される生物種
Full Name latent transforming growth factor beta binding protein 2
Calculated molecular weight 1821 aa, 195 kDa
Observed molecular weight290 kDa
GenBank accession numberBC078659
Gene symbol LTBP2
Gene ID (NCBI) 4053
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

LTBP2, an extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-β binding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma (PMID: 20179738 ) . LTBP2 is a biomarker of heart failure. LTBP2 has a molecular weight of 260 kDa (PMID: 20878956), and even larger molecular weights of 290 and 310 kDa were detected in tissue extracts. (PMID: 8524260)