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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using MERTK Polyclonal antibody (27900-1-AP)

    WB analysis using 27900-1-AP (same clone as 27900-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27900-1-AP (MERTK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat liver tissue using MERTK Polyclonal antibody (27900-1-AP)

    IHC staining of rat liver using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung tissue using MERTK Polyclonal antibody (27900-1-AP)

    IHC staining of human lung using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse lung tissue using MERTK Polyclonal antibody (27900-1-AP)

    IHC staining of mouse lung using 27900-1-AP (same clone as 27900-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 27900-1-AP (MERTK antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of Jurkat cells using MERTK Polyclonal antibody (27900-1-AP)

    FC experiment of Jurkat using 27900-1-AP (same clone as 27900-1-PBS)

    1x10^6 Jurkat cells were intracellularly stained with 0.25 ug MERTK Polyclonal antibody (27900-1-AP) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 27900-1-PBS in a different storage buffer formulation.

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MERTK Polyclonal antibody, PBS Only

MERTK Polyclonal Antibody for WB, IHC, FC (Intra), Indirect ELISA
Cat No. 27900-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, FC (Intra), Indirect ELISA

Synonyms

Receptor tyrosine kinase MerTK, Proto-oncogene c-Mer, Proto oncogene c Mer, MER, EC:2.7.10.1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

27900-1-PBS targets MERTK in WB, IHC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MERTK fusion protein Ag27540 相同性解析による交差性が予測される生物種
Full Name c-mer proto-oncogene tyrosine kinase
Calculated molecular weight 999 aa, 110 kDa
Observed molecular weight160-180 kDa
GenBank accession numberBC114918
Gene Symbol MERTK
Gene ID (NCBI) 10461
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ12866
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

MerTK (Mer tyrosine kinase), also known as RP38, c-Eyk, c-mer, and Tyro12, was first cloned from a human B lymphoblastoid expression library (PMID:8086340) and is one of the TAM (Tyro-3, Axl, and MerTK) receptor tyrosine kinase (RTK) family (PMID:23833304). Although this RTK, like others, can promote tumor cell proliferation to some extent, MERTK primarily lends tumor cells crucial survival advantages while promoting invasion, migration and metastasis, drug resistance, and, in the innate immune system, suppressing anti-tumor immunity (PMID:32417270). The multiple MERTK species observed are likely due to posttranslational modifications (PMID: 23585477).