- Featured Product
- KD/KO Validated
MGP Monoclonal antibody, PBS Only
MGP Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human, mouse
Applications
WB, IHC, IF-P, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1A1C3
Cat no : 60055-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60055-1-PBS targets MGP in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | MGP fusion protein Ag1091 相同性解析による交差性が予測される生物種 |
Full Name | matrix Gla protein |
Calculated molecular weight | 103 aa, 13 kDa |
Observed molecular weight | 12 kDa |
GenBank accession number | BC005272 |
Gene symbol | MGP |
Gene ID (NCBI) | 4256 |
RRID | AB_2143330 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.