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- KD/KO Validated
MLPH Polyclonal antibody, PBS Only
MLPH Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, IF/ICC, IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 10338-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
10338-1-PBS targets MLPH in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | MLPH fusion protein Ag0316 相同性解析による交差性が予測される生物種 |
Full Name | melanophilin |
Calculated molecular weight | 66 kDa |
Observed molecular weight | 66 kDa, 80 kDa |
GenBank accession number | BC001653 |
Gene symbol | MLPH |
Gene ID (NCBI) | 79083 |
RRID | AB_2146104 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Melanophilin (Mlph) is a member of the exophilin subfamily of Rab effector proteins. MLPH is a modular protein, forming a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. It regulates retention of melanosomes at the peripheral actin cytoskeleton of melanocytes, a process essential for normal mammalian pigmentation. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3), which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft.