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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using MPC1 Polyclonal antibody (30868-1-AP)

    WB analysis using 30868-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 30868-1-AP (BRP44L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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MPC1 Polyclonal antibody

MPC1 Polyclonal Antibody for WB, ELISA
Cat No. 30868-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

BRP44L, PNAS 115, HSPC040, CGI 129, Brain protein 44 like protein

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHL-60 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

30868-1-AP targets MPC1 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MPC1 fusion protein Ag28826 相同性解析による交差性が予測される生物種
Full Name brain protein 44-like
Calculated molecular weight 12 kDa
Observed molecular weight12 kDa, 20-24 kDa
GenBank accession numberBC000810
Gene Symbol BRP44L
Gene ID (NCBI) 51660
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9Y5U8
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

MPC1, also known as BRP44L. BRP44L is predicted to be located in Mitochondrion inner membrane. The protein forms a heterodimer with MPC2, and the heterodimer is a more stable and dominant form (PMID:26253029, PMID:32403431). Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. Yeast and Drosophila mutants lacking MPC1 display impaired pyruvate metabolism, with an accumulation of upstream metabolites and a depletion of tricarboxylic acid cycle intermediates. Loss of yeast Mpc1 results in defective mitochondrial pyruvate uptake, and silencing of MPC1 or MPC2 in mammalian cells impairs pyruvate oxidation. A point mutation in MPC1 provides resistance to a known inhibitor of the mitochondrial pyruvate carrier (PMID: 22628558).The molecular weight of MPC1 is 12 kDa.

Protocols

Product Specific Protocols
WB protocol for MPC1 antibody 30868-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols