MTH1 Monoclonal antibody, PBS Only
MTH1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2D7G4
Cat no : 67443-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
67443-1-PBS targets MTH1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse samples.
Tested Reactivity | Human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | MTH1 fusion protein Ag9802 相同性解析による交差性が予測される生物種 |
Full Name | nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
Calculated molecular weight | 179aa,20 kDa; 197aa,23 kDa |
Observed molecular weight | 19 kDa |
GenBank accession number | BC014618 |
Gene symbol | NUDT1 |
Gene ID (NCBI) | 4521 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
MTH1, also known as NUDT1 or 8-Oxo-dGTPase, is an important repair enzyme that prevents oxidative stress-induced DNA damage through hydrolyzing mutagenic 8-oxo-dGTP into 8-oxo-dGMP. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. MTH1 might be a useful marker of oxidative stress and its level increased upon oxidative stress. Increased expression of MTH1 were also found in various cancer tissues and neurodegenerative diseases.