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Host
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Species Reactivity
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Conjugate
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Conjugate
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Conjugate
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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

MTMR15 Recombinant antibody, PBS Only

MTMR15 Recombinant Antibody for FC (Intra), Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra), Indirect ELISA

Conjugate

Unconjugated

CloneNo.

240629E4

Cat no : 83622-6-PBS

Synonyms

hFAN1, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, FAN1, EC:3.1.21.-

Validation Data Gallery

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  • Flow cytometry (FC) experiment of K-562 cells using MTMR15 Recombinant antibody (83622-6-RR)

    FC experiment of K-562 using 83622-6-RR (same clone as 83622-6-PBS)

    1x10^6 K-562 cells were intracellularly stained with 0.25 ug Mtmr15 Recombinant Antibody (83622-6-RR, Clone:240629E4) (red), or 0.25 ug Isotype Control (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). This data was developed using the same antibody clone with 83622-6-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of A431 cells using MTMR15 Recombinant antibody (83622-6-RR)

    FC experiment of A431 using 83622-6-RR (same clone as 83622-6-PBS)

    1x10^6 A431 cells were intracellularly stained with 0.25 ug Mtmr15 Recombinant Antibody (83622-6-RR, Clone:240629E4)(red), or 0.25 ug Isotype Control (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). This data was developed using the same antibody clone with 83622-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83622-6-RR

    Affinity and Kinetic Characterization of 83622-6-RR

    Biolayer interferometry (BLl) kinetic assays of 83622-6-RR against Human MTMR15 were performed. The affinity constant is 3.74 nM.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

The immunogen of 83622-6-PBS is MTMR15 Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen MTMR15 fusion protein Ag11651 相同性解析による交差性が予測される生物種
Full Name myotubularin related protein 15
Calculated molecular weight 60 kDa, 114 kDa
GenBank accession numberBC047882
Gene symbol MTMR15
Gene ID (NCBI) 22909
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

MTMR15, also named as FAN1 and KIAA1018, is a nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. It is specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. MTMR15 has some isoforms with MW 114 kDa and 60 kDa. The MW will be migrated to 120-140 kDa and 63-68 kDa with modification.