MultiPro™ 5CFLX Anti-Human IL-17A (1F3E3)
NeutraKine® IL-17A Monoclonal Antibody for Single Cell (Intra)
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
Conjugate
5CFLX
Barcode Sequence
CTAGCGCTACCTAAC
CloneNo.
1F3E3
Cat no : G69021-1-5C
Synonyms
Validation Data Gallery
Tested Applications
| Positive Single Cell (Intra) detected in | 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product |
Recommended dilution
| Application | Dilution |
|---|---|
| SINGLE CELL (INTRA) | <0.5ug/test |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
G69021-1-5C targets NeutraKine® IL-17A in Single Cell (Intra) applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Oligo Conjugate |
| Type | Monoclonal |
| Immunogen | NeutraKine® IL-17A fusion protein HZ-1113 相同性解析による交差性が予測される生物種 |
| Full Name | MultiPro™ 5CFLX Anti-Human IL-17A (1F3E3) |
| Gene symbol | IL-17A |
| Gene ID (NCBI) | 3605 |
| Conjugate | 5CFLX |
| Full Oligo Sequence | CGGAGATGTGTATAAGAGACAGCTAGCGCTACCTAACCCCATATAAGAAA |
| Barcode Sequence | CTAGCGCTACCTAAC |
| Form | Liquid |
| Storage Buffer | PBS with 1mM EDTA and 0.09% sodium azide |
| Storage Conditions | 2-8°C Stable for one year after shipment. |
Background Information
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
This antibody can be used to neutralize the bioactivity of IL-17A.
Protocols
| MultiPro™ Cell Surface and Intracellular Staining Protocol | Download protocol |
| 10x Genomics Cell Surface Protein Only Staining Protocol | Download protocol |
