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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

MultiPro® 5CFLX Anti-Human SYK (4C4A12)

SYK Monoclonal Antibody for Single Cell (Intra)

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

Single Cell (Intra)

Conjugate

5CFLX

Barcode Sequence

CGTGATGCGCTGACG

CloneNo.

4C4A12

Cat no : G66721-1-5C

Synonyms

DKFZp313N1010, FLJ25043, FLJ37489, spleen tyrosine kinase, SYK, Tyrosine protein kinase SYK

Validation Data Gallery

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  • Single Cell Sequencing experiment G66721-1-5C on Resting PBMC

    Single Cell Sequencing experiment G66721-1-5C on Resting PBMC

    G66721-1-5C was used to stain Resting PBMC and analyzed with 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing kit with Fix-Stain protocol.

  • Single Cell Sequencing experiment G66721-1-5C on PBMC treated with 4hr LPS + TI

    Single Cell Sequencing experiment G66721-1-5C on PBMC treated with 4hr LPS + TI

    G66721-1-5C was used to stain PBMC under 4hr LPS + TI treatment and analyzed with 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing kit with Fix-Stain protocol.

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Tested Applications

Positive Single Cell (Intra) detected in10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product

Recommended dilution

ApplicationDilution
SINGLE CELL (INTRA)<0.5ug/test
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

G66721-1-5C targets SYK in Single Cell (Intra) applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Oligo Conjugate
Type Monoclonal
Immunogen SYK fusion protein Ag17654 相同性解析による交差性が予測される生物種
Full Name MultiPro® 5CFLX Anti-Human SYK (4C4A12)
Calculated molecular weight 635 aa, 72 kDa
GenBank accession numberBC001645
Gene symbol SYK
Gene ID (NCBI) 6850
Conjugate 5CFLX
Full Oligo SequenceCGGAGATGTGTATAAGAGACAGCGTGATGCGCTGACGCCCATATAAGAAA
Barcode SequenceCGTGATGCGCTGACG
Form Liquid
Storage Buffer PBS with 1mM EDTA and 0.09% sodium azide
Storage Conditions2-8°C Stable for one year after shipment.

Background Information

SYK(spleen tyrosine kinase) is a key regulator of signal transduction events,apoptosis and orderly cell cycle progression in B-lineage lymphoid cells. Although SYK has not been linked to a human disease, defective expression of the closely related T-cell tyrosine kinase ZAP-70 has been associated with severe combined immunodeficiency(PMID:11494125). This protein has 2 isoforms produced by alternative splicing. SYK also promotes liver fibrosis by activation of hepatic stellate cells and acts as a biomarker for human hepatocellular carcinoma. (PMID: 29537660)

Protocols

MultiPro™ Cell Surface and Intracellular Staining ProtocolDownload protocol
10x Genomics Cell Surface Protein Only Staining ProtocolDownload protocol