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Species Reactivity
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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Mouse NK1.1 (CD161) (PK136)

NK1.1 (CD161) Monoclonal Antibody for FC

Host / Isotype

Mouse / IgG2a, kappa

Reactivity

Mouse

Applications

FC

Conjugate

Unconjugated

CloneNo.

PK136

Cat no : 65138-1-Ig

Synonyms

CD161, Klrb1a, Ly55a, NK1.1, NK1.1 (CD161), NKR P1A, Nkrp1 a, NKRP12, Nkrp1a

Validation Data Gallery

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  • Flow cytometry (FC) experiment of C57BL/6 mouse splenocytes using Anti-Mouse NK1.1 (CD161) (PK136) (65138-1-Ig)

    FC experiment of C57BL/6 mouse splenocytes using 65138-1-Ig

    1X10^6 C57BL/6 mouse splenocytes were surface co-stained with APC Anti-Mouse CD49b (DX5) and 0.5 ug Anti-Mouse NK1.1 (CD161) (65138-1-Ig, Clone:PK136) and FITC anti-Mouse IgG2a Antibody at dilution 1:100, or 0.5 ug Mouse IgG2a Isotype Control (C1.18.4) and FITC anti-Mouse IgG2a Antibody at dilution 1:100. Cells were not fixed.

  • Flow cytometry (FC) experiment of C57BL/6 mouse splenocytes using Anti-Mouse NK1.1 (CD161) (PK136) (65138-1-Ig)

    FC experiment of C57BL/6 mouse splenocytes using 65138-1-Ig

    1X10^6 C57BL/6 mouse splenocytes were surface stained with 0.5 ug Anti-Mouse NK1.1 (CD161) (65138-1-Ig, Clone:PK136) and FITC anti-Mouse IgG2a Antibody at dilution 1:100, or 0.5 ug Mouse IgG2a Isotype Control (C1.18.4) and FITC anti-Mouse IgG2a Antibody at dilution 1:100. Cells were not fixed.

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Tested Applications

Positive FC detected inC57BL/6 mouse splenocytes

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65138-1-Ig targets NK1.1 (CD161) in FC applications and shows reactivity with Mouse samples.

Tested Reactivity Mouse
Host / Isotype Mouse / IgG2a, kappa
Class Monoclonal
Type Antibody
Immunogen NK-1+ cells from mouse spleen and bone marrow 相同性解析による交差性が予測される生物種
Full Name killer cell lectin-like receptor subfamily B member 1A
GenBank accession numberBC120707
Gene symbol NK1.1
Gene ID (NCBI) 17057
RRIDAB_2918425
Conjugate Unconjugated
Form Liquid
Purification MethodAffinity purification
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Stable for one year after shipment.

Background Information

NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).

Protocols

Product Specific Protocols
FC protocol for NK1.1 (CD161) antibody 65138-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols