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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using NLRP12 Polyclonal antibody (30998-1-AP)

    WB analysis using 30998-1-AP (same clone as 30998-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30998-1-AP (NLRP12 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30998-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of rat liver tissue using NLRP12 Polyclonal antibody (30998-1-AP)

    IP experiment of rat liver using 30998-1-AP (same clone as 30998-1-PBS)

    IP result of anti-NLRP12 (IP:30998-1-AP, 4ug; Detection:30998-1-AP 1:500) with rat liver tissue lysate 2695 ug. This data was developed using the same antibody clone with 30998-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of PC-3 cells using NLRP12 Polyclonal antibody (30998-1-AP)

    IP experiment of PC-3 using 30998-1-AP (same clone as 30998-1-PBS)

    IP result of anti-NLRP12 (IP:30998-1-AP, 4ug; Detection:30998-1-AP 1:500) with PC-3 cells lysate 1575 ug. This data was developed using the same antibody clone with 30998-1-PBS in a different storage buffer formulation.

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NLRP12 Polyclonal antibody, PBS Only

NLRP12 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 30998-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Synonyms

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

30998-1-PBS targets NLRP12 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NLRP12 fusion protein Ag34281 相同性解析による交差性が予測される生物種
Full Name NLR family, pyrin domain containing 12
Calculated molecular weight 1061 aa, 120 kDa
Observed molecular weight 95-110 kDa
GenBank accession numberBC028069
Gene Symbol NLRP12
Gene ID (NCBI) 91662
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity Purification
UNIPROT IDP59046
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

NACHT, LRR and PYD domains-containing protein 12 (NLRP12) is also named as Monarch-1, NALP12, PYPAF7 and RNO. NLRP12 is as an essential cytosolic sensor for heme plus PAMPs-mediated PANoptosis, inflammation, and pathology (PMID: 37267949). NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF. TLR2/4-mediated signaling through IRF1 induced Nlrp12 expression, which led to inflammasome formation to induce maturation of IL-1β and IL-18 (PMID: 37267949). NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production (PMID: 36719379).