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NLRP6 Recombinant antibody, PBS Only

NLRP6 Uni-rAbTM Recombinant Antibody for WB, IF/ICC, ELISA
Cat No. 83555-5-PBS
Clone No.240543B2

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IF/ICC, ELISA

PYPAF5, NALP6, 240543B2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration:  100 μg, 1 mg/ml
100 μg, 1 mg/ml

¥167,000/ 100 μg

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

83555-5-PBS targets NLRP6 in WB, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen NLRP6 fusion protein Ag34516 相同性解析による交差性が予測される生物種
Full Name NLR family, pyrin domain containing 6
Calculated molecular weight99 kDa
Observed molecular weight 98 kDa
GenBank accession numberNM_138329.2
Gene Symbol NLRP6
Gene ID (NCBI) 171389
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP59044
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

NOD-like receptor family pyrin domain containing 6 (NLRP6) is also named as NACHT, LRR and PYD domains-containing protein 6 and ZFML, Angiotensin II/vasopressin receptor, NALP6 and PYPAF5. NLRP6 forms a complex with ASC and caspase-1 or caspase-11 to form an inflammasome complex cleaving pro-interleukin-1β (IL-1β) and IL-18 into their biologically active forms. The function of NLRP6 has been attributed to the maintenance of epithelial integrity and host defense against microbial infections (PMID: 33910012). NLRP6 is reported to involved in inflammasome activation, regulation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling, antiviral interferon (IFN) signaling, mucus secretion, and antimicrobial peptide (AMP) production. NLRP6 is a novel NLR family member, that shows high expression in the intestine and liver (in contrast to NLRP3 in myeloid cells), to regulate inflammation and host defense against microbes (PMID: 32386845).

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