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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

NMDAR2B/GRIN2B Monoclonal antibody, PBS Only

NMDAR2B/GRIN2B Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C5E12

Cat no : 66565-1-PBS

Synonyms

GluN2B, GRIN2B, hNR3, NMDAR2B, NMDAR2B/GRIN2B, NR2B, NR3

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using NMDAR2B/GRIN2B Monoclonal antibody (66565-1-Ig)

    WB analysis of mouse brain using 66565-1-Ig (same clone as 66565-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 66565-1-Ig (NMDAR2B/GRIN2B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66565-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat brain tissue using NMDAR2B/GRIN2B Monoclonal antibody (66565-1-Ig)

    WB analysis of rat brain using 66565-1-Ig (same clone as 66565-1-PBS)

    rat brain tissue were subjected to SDS PAGE followed by western blot with 66565-1-Ig (NMDAR2B/GRIN2B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66565-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

66565-1-PBS targets NMDAR2B/GRIN2B in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Reactivity Human, Mouse, Rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen NMDAR2B/GRIN2B fusion protein Ag16718 相同性解析による交差性が予測される生物種
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Calculated molecular weight 1484 aa, 166 kDa
Observed molecular weight 166 kDa
GenBank accession numberBC113620
Gene symbol GRIN2B
Gene ID (NCBI) 2904
RRIDAB_2881926
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.