Validation Data Gallery
Tested Applications
| Positive WB detected in | transfected cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:200-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| WB | See 3 publications below |
Product Information
55113-1-AP targets NPR2 in WB, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) |
| Calculated molecular weight | 117 kDa |
| Observed molecular weight | 111 kDa, 117 kDa |
| GenBank accession number | NM_003995 |
| Gene Symbol | NPR2 |
| Gene ID (NCBI) | 4882 |
| RRID | AB_2881270 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P20594 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
Background Information
NPR2, also named as ANPRB, GC-B, NPR-B, ANPR-B and ANP-B, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It is a receptor for the C-type natriuretic peptide NPPC/CNP hormone. NRP2 has guanylate cyclase activity upon binding of its ligand. It may play a role in the regulation of skeletal growth. NPR2 is the primary receptor for C type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM). The antibody is specific to NPR2.
Publications
| Species | Application | Title |
|---|---|---|
Int J Mol Sci Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation | ||
Proc Natl Acad Sci U S A Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor | ||
bioRxiv EVIDENCE FOR ANGIOTENSIN II AS A NATURALLY EXISTING SUPPRESSOR FOR THE NATRIURETIC PEPTIDE SYSTEM |