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  • Featured Product
  • KD/KO Validated

NR1H2 Monoclonal antibody, PBS Only

NR1H2 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, pig

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1E12B10

Cat no : 60345-1-PBS

Synonyms

Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR

Validation Data Gallery

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  • Western Blot (WB) analysis of human liver tissue using NR1H2 Monoclonal antibody (60345-1-Ig)

    WB analysis of human liver using 60345-1-Ig (same clone as 60345-1-PBS)

    human liver tissue were subjected to SDS PAGE followed by western blot with 60345-1-Ig (NR1H2 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60345-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of pig liver tissue using NR1H2 Monoclonal antibody (60345-1-Ig)

    WB analysis of pig liver using 60345-1-Ig (same clone as 60345-1-PBS)

    pig liver tissue were subjected to SDS PAGE followed by western blot with 60345-1-Ig (NR1H2 Antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60345-1-PBS in a different storage buffer formulation.

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

60345-1-PBS targets NR1H2 in WB, ELISA applications and shows reactivity with human, pig samples.

Tested Reactivity human, pig
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen NR1H2 fusion protein Ag5635 相同性解析による交差性が予測される生物種
Full Name nuclear receptor subfamily 1, group H, member 2
Calculated molecular weight 51 kDa
Observed molecular weight 51 kDa
GenBank accession numberBC047750
Gene symbol NR1H2
Gene ID (NCBI) 7376
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

Background Information

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.