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Validation Data Gallery

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  • Immunoprecipitation (IP) experiment of THP-1 cells using NUDT18 Polyclonal antibody (17318-1-AP)

    IP experiment of THP-1 using 17318-1-AP

    IP result of anti-NUDT18 (IP:17318-1-AP, 4ug; Detection:17318-1-AP 1:500) with THP-1 cells lysate 2480 ug.

  • Immunofluorescence (IF) / fluorescent staining of THP-1 cells using NUDT18 Polyclonal antibody (17318-1-AP)

    IF Staining of THP-1 using 17318-1-AP

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using NUDT18 antibody (17318-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002).

［PR］まずは試したいあなたに。トライアルサイズも特別価格 >>『PRIME BUY抗体特割キャンペーン（4/21～）』

NUDT18 Polyclonal antibody

NUDT18 Polyclonal Antibody for IF/ICC, IP, ELISA
Cat No. 17318-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, IP, ELISA

Synonyms

MTH3, Nucleoside diphosphate-linked moiety X motif 18, EC:3.6.1.58, 8-oxo-dGDP phosphatase NUDT18, 7,8-dihydro-8-oxoguanine phosphatase

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive IP detected inTHP-1 cells
Positive IF/ICC detected inTHP-1 cells

Recommended dilution

ApplicationDilution
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunofluorescence (IF)/ICCIF/ICC : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

17318-1-AP targets NUDT18 in IF/ICC, IP, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NUDT18 fusion protein Ag11292 相同性解析による交差性が予測される生物種
Full Name nudix (nucleoside diphosphate linked moiety X)-type motif 18
Calculated molecular weight 323 aa, 36 kDa
Observed molecular weight36 kDa
GenBank accession numberBC016902
Gene Symbol NUDT18
Gene ID (NCBI) 79873
RRIDAB_3669267
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ6ZVK8
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

8-oxo-dGDP phosphatase NUDT18, also known as MTH3, belongs to the Nudix hydrolase family that eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of various nucleotide substrates, cofactors, and signaling molecules (PMID: 35732208, 22556419). NUDT18 is specifically active against 8-oxo-dGDP and hardly cleaves 8-oxo-dGTP. NUDT18 is markedly elevated expression in noncancerous cell lines in comparison to cancerous counterpart, and NUDT18 deficient cells have been reported to exhibit a noticeably reduced proliferation rate (PMID: 38944687).

Protocols

Product Specific Protocols
IF protocol for NUDT18 antibody 17318-1-APDownload protocol
IP protocol for NUDT18 antibody 17318-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols