Validation Data Gallery
Product Information
69520-1-PBS targets PDGF-BB in ELISA, Non-Neutralization applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
Product name: HumanKine® recombinant human PDGFbb protein Source: -derived, Tag: Sequence: 相同性解析による交差性が予測される生物種 |
| Full Name | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) |
| Gene Symbol | PDGFB |
| Gene ID (NCBI) | 5155 |
| Conjugate | Unconjugated |
| Form | |
| Purification Method | Protein A purification |
| UNIPROT ID | P01127 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Endotoxin | <0.1 EU/μg |
| Storage Conditions | Store at -80°C. |
Background Information
Platelet-derived growth factor (PDGF) belongs to the family of growth factors consisting of four secreted extracellular ligands including PDGF-A, -B, -C and -D. These isoforms, PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD, act via two receptor tyrosine kinases, PDGF receptors alpha and beta. PDGF isoforms stimulate growth, survival and motility of mesenchymal cells and certain other cell type. They have important functions during embryonal development and in the control of tissue homeostasis in the adult. PDGF-BB is one of the most recently studied isoforms and it plays an important role in skeletal development. PDGF-BB stimulates cell-mediated collagen gel contraction. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.
This antibody is a neutralizing control antibody for PDGF-BB, the immunogen is the same as Neutrakine 69020-1-Ig but could not neutralize human PDGF-BB.