NeutraKine® IFN beta Monoclonal antibody
NeutraKine® IFN beta Monoclonal Antibody for ELISA, Neutralization
Host / Isotype
Mouse / IgG1
Reactivity
Human and More (2)
Applications
ELISA, Neutralization
Conjugate
Unconjugated
CloneNo.
2C6E5
Cat no : 69013-1-Ig
Synonyms
Validation Data Gallery
| Neutralization |
Product Information
69013-1-Ig targets NeutraKine® IFN beta in ELISA, Neutralization applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Cited Reactivity | human, mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | human Humankine IFN beta protein HZ-1298 相同性解析による交差性が予測される生物種 |
| Full Name | IFN beta |
| Gene symbol | IFN beta1 |
| Gene ID (NCBI) | 3456 |
| RRID | AB_2882931 |
| Conjugate | Unconjugated |
| Form | Lyophilized Powder |
| Purification Method | Protein G purification |
| Storage Buffer | Sterile PBS. |
| Endotoxin | <0.1 EU/μg |
| Reconstitution | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Background Information
Interferon beta (IFN beta) is a cytokine that is naturally produced by the immune system in response to biological and chemical stimuli. It signals by binding to the heterodimeric type I IFN receptor composed of the IFNAR1 and IFNAR2 chains, and regulates the expression of a plethora of genes by means of the classical JAK/STAT and other pathways. Interferon beta (IFN beta) has been shown in several clinical trials to have efficacy in multiple sclerosis. Interferon beta gene therapy is expected to become widely available for clinical use in cancer patients, and this new strategy might be extended to molecular targeting therapy, or used in combination with cell therapy or other therapies.
This antibody can be used to neutralize the bioactivity of IFN beta.
Publications
| Species | Application | Title |
|---|---|---|
Nat Commun Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association. | ||
Cell Rep Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis |
