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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

OPN4 Polyclonal antibody

OPN4 Polyclonal Antibody for IF-P, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IF-P, ELISA

Conjugate

Unconjugated

Cat no : 24478-1-AP

Synonyms

Opsin-4, opsin 4, MOP, Melanopsin

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of mouse eye tissue using OPN4 Polyclonal antibody (24478-1-AP)

    IF Staining of mouse eye using 24478-1-AP

    Immunofluorescent analysis of (4% PFA) fixed mouse eye tissue using OPN4 antibody (24478-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L).

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Tested Applications

Positive IF-P detected inmouse eye tissue

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

24478-1-AP targets OPN4 in IF-P, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen OPN4 fusion protein Ag21643 相同性解析による交差性が予測される生物種
Full Name opsin 4
Calculated molecular weight 478 aa, 53 kDa
GenBank accession numberBC113558
Gene symbol OPN4
Gene ID (NCBI) 94233
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

OPN4, an opsin that was first isolated from the skin of Xenopus laevis in 1998, belongs not to the vertebrate-type opsin family but rather to the invertebrate-type opsins, which are part of the seven-transmembrane G protein-coupled receptor (GPCR) family (PMID:31989708). In humans, OPN4 is expressed in the retinal ganglion cells in addition to part of the brain (PMID:10632589). Moreover, Opn4 functions as a photoreceptor by detecting brightness levels and discriminating visual signals (PMID:22633808). Opn4 also facilitates visual circuits to acquire optimal settings and light adaptation by measuring irradiance levels (PMID:25517373).

Protocols

Product Specific Protocols
IF protocol for OPN4 antibody 24478-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols