PARK7/DJ-1 Monoclonal antibody, PBS Only
PARK7/DJ-1 Monoclonal Antibody for WB, FC (Intra), Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat, pig, rabbit
Applications
WB, FC (Intra), Indirect ELISA
Conjugate
Unconjugated
CloneNo.
4G4E7
Cat no : 68915-6-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
68915-6-PBS targets PARK7/DJ-1 in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat, pig, rabbit samples.
| Tested Reactivity | human, mouse, rat, pig, rabbit |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | PARK7/DJ-1 fusion protein Ag28526 相同性解析による交差性が予測される生物種 |
| Full Name | Parkinson disease (autosomal recessive, early onset) 7 |
| Calculated molecular weight | 189 aa, 20 kDa |
| Observed molecular weight | 20-25 kDa |
| GenBank accession number | BC008188 |
| Gene symbol | PARK7 |
| Gene ID (NCBI) | 11315 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
PARK7, also named as DJ1, belongs to the peptidase C56 family. It protects cells against oxidative stress and cell death. PARK7 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. It eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. PARK7 has cell-growth promoting activity and transforming activity. It may function as a redox-sensitive chaperone. It's precursor undergoes a cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress. The amino acid replace at 166 (L → P) reduces PARK7 protein stability and leads to increased degradation. The predicted MW of this protein is 20 kDa, An additional 25 kDa band can be observed due to modification (PMID: 31767755).
