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PGRMC1 Monoclonal antibody, PBS Only

PGRMC1 Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, Indirect ELISA
Cat No. 66372-1-PBS
Clone No.1C10D11

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat, pig

Applications

WB, IHC, IF/ICC, IF-P, Indirect ELISA

PGRMC, mPR, Membrane-associated progesterone receptor component 1, HPR6.6, 1C10D11

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration:  100 μg, 1mg/ml
100 μg, 1mg/ml

¥167,000/ 100 μg

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

66372-1-PBS targets PGRMC1 in WB, IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Reactivity human, mouse, rat, pig
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen PGRMC1 fusion protein Ag3643 相同性解析による交差性が予測される生物種
Full Name progesterone receptor membrane component 1
Calculated molecular weight 195 aa, 22 kDa
Observed molecular weight 25-27 kDa
GenBank accession numberBC034238
Gene Symbol PGRMC1
Gene ID (NCBI) 10857
RRIDAB_2881751
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO00264
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297).

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