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PLA2R1 Polyclonal antibody
PLA2R1 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, ELISA
Conjugate
Unconjugated
Cat no : 18798-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
KD/KO | See 1 publications below |
WB | See 1 publications below |
Product Information
18798-1-AP targets PLA2R1 in WB, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Cited Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
Full Name | phospholipase A2 receptor 1, 180kDa |
Calculated molecular weight | 168 kDa |
GenBank accession number | BC144631 |
Gene symbol | PLA2R1 |
Gene ID (NCBI) | 22925 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Secretory phospholipase A2 (sPLA2) are implicated in a number of crucial physiological and pathological processes in mammals. Different types of membrane receptors for sPLA2s have been identified. The M-type receptor, PLA2R1 (phospholipase A2 receptor 1, 180 kDa), is a type I transmembrane glycoprotein containing extracellularly a cysteine-rich domain, a fibronectin type II domain and eight carbohydrate-recognition domains. It is a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. PLA2R1 may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. It has been recently shown that PLA2R1 is the major target antigen in idiopathic membranous nephropathy (iMN). Patients with iMN have antibodies against a conformation-dependent epitope in PLA2R1.
Publications
Species | Application | Title |
---|---|---|
Mol Pharm Role of the Phospholipase A2 Receptor in Liposome Drug Delivery in Prostate Cancer Cells.
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