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PLXNB1 Polyclonal antibody

PLXNB1 Polyclonal Antibody for WB, IHC, ELISA
Cat No. 23795-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

WB, IF, IHC, ELISA

KIAA0407, plexin B1, PLXN5, PLXNB1, Semaphorin receptor SEP, SEP

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -


ご購入について

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inmouse brain tissue
Positive IHC detected inhuman kidney tissue, human brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

23795-1-AP targets PLXNB1 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PLXNB1 fusion protein Ag20719 相同性解析による交差性が予測される生物種
Full Name plexin B1
Calculated molecular weight 2135 aa, 232 kDa
Observed molecular weight 210 kDa
GenBank accession numberBC146793
Gene Symbol PLXNB1
Gene ID (NCBI) 5364
RRIDAB_2879326
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
UNIPROT IDO43157
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Semaphorins, originally identified as axon guidance molecules, have also been implicated in angiogenesis, immunoregulation, and cancer (PMID: 16584533). Plexins are main receptors for semaphorins and are thought to control many of the functional effects of semaphorins. PLXNB1 is one of the three plexin-B family members. It is a high-affinity receptor for semaphorin 4D (SEMA4D). Interaction of SEMA4D and PLXNB1 has important physiologic effects in the immune and nervous systems, and is also involved in tumor progression, especially in tumor angiogenesis (PMID: 20858260).

Protocols

Product Specific Protocols
WB protocol for PLXNB1 antibody 23795-1-APDownload protocol
IHC protocol for PLXNB1 antibody 23795-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseFC

Cancer Immunol Res

Semaphorin4D Inhibition Improves Response to Immune-Checkpoint Blockade via Attenuation of MDSC Recruitment and Function.

Authors - Paul E Clavijo
humanWB

J Transl Med

SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling.

Authors - Lu Liu
ratWB

Ann Transl Med

Proteomics and metabolomics of raw rhubarb and wine-processed rhubarb in the treatment of rats with intracerebral hemorrhage.

Authors - Kun Wang
mouseIF

J Neuroendocrinol

PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism.

Authors - Bradley A Welch
humanIHC

Ann Transl Med

Methylation-based epigenetic studies and gene integration analysis of preeclampsia

Authors - Lei Jiang
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