PNRC2 Polyclonal antibody

PNRC2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, ChIP, ELISA

Conjugate

Unconjugated

Cat no : 51050-1-AP

Synonyms

Proline-rich nuclear receptor coactivator 2, HSPC208


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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

51050-1-AP targets PNRC2 in WB, IHC, ChIP, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PNRC2 fusion protein Ag0099 相同性解析による交差性が予測される生物種
Full Name proline-rich nuclear receptor coactivator 2
Calculated molecular weight 16 kDa
Observed molecular weight 25 kDa
GenBank accession numberBC001959
Gene symbol PNRC2
Gene ID (NCBI) 55629
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

PNRC2 belongs to the PNRC family and PNRC2 subfamily. It is Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. It is required for UPF1/RENT1 localization to the P-body. PNRC2 also acts as a nuclear receptor coactivator. It may play a role in controlling the energy balance between energy storage and energy expenditure. (PMID:19150429) PNRC2 functions as a coactivator of several nuclear receptors, including ERRa, and participates in the activation of aromatase in conjunction with ERRa. Growth factor signaling promotes PELP1 recruitment to the aromatase chromatin and its formation of a complex with ERRa and PNRC2.(PMID:18079323)

Publications

SpeciesApplicationTitle
humanWB,IHC,ChIP

Mol Endocrinol

Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells.

Authors - Rajhans Rajib R