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- KD/KO Validated
PRDX1 Monoclonal antibody, PBS Only
PRDX1 Monoclonal Antibody for WB, IF, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse , rat
Applications
WB, IF, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2B2A2
Cat no : 66820-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66820-1-PBS targets PRDX1 in WB, IF, IHC, Indirect ELISA applications and shows reactivity with Human, mouse , rat samples.
Tested Reactivity | Human, mouse , rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | PRDX1 fusion protein Ag8821 相同性解析による交差性が予測される生物種 |
Full Name | peroxiredoxin 1 |
Calculated molecular weight | 199 aa, 22 kDa |
Observed molecular weight | 23 kDa |
GenBank accession number | BC007063 |
Gene symbol | PRDX1 |
Gene ID (NCBI) | 5052 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
PRDX1(Peroxiredoxin-1), also named as PAGA, PAGB, TDPX2, PAG or NKEF-A, belongs to the ahpC/TSA family. PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 ((PMID: 9497357)). It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. PRDX1 can form a dimer, and also can be phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity (PMID: 22583657, 11986303).