PTPRO Monoclonal antibody, PBS Only
PTPRO Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, Pig
Applications
WB, IHC, IF-P, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2F2B4
Cat no : 67000-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
67000-1-PBS targets PTPRO in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, Pig samples.
Tested Reactivity | Human, Pig |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | PTPRO fusion protein Ag8284 相同性解析による交差性が予測される生物種 |
Full Name | protein tyrosine phosphatase, receptor type, O |
Calculated molecular weight | 138 kDa |
Observed molecular weight | 160 kDa, 180-220 kDa |
GenBank accession number | BC035960 |
Gene symbol | PTPRO |
Gene ID (NCBI) | 5800 |
RRID | AB_2882317 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
PTPRO(receptor-type tyrosine-protein phosphatase O) is also named as GLEPP1, PTPU2 and belongs to the protein-tyrosine phosphatase family. The protein is a receptor-like membrane protein tyrosine phosphatase expressed at the apical membrane of the podocyte foot processes in the kidney(PMID:21722858). The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). In reducing conditions, PTPRO can form a smear from 180 to 220 kDa; In non-reducing conditions, a band appeares around 350 kDa, which likely represents the dimeric form of full-length PTPRO (PMID: 19573017).