Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66923-1-PBS targets ROR1 as part of a matched antibody pair:
MP51139-1: 66923-2-PBS capture and 66923-1-PBS detection (validated in Cytometric bead array)
MP51139-2: 66923-3-PBS capture and 66923-1-PBS detection (validated in Cytometric bead array)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | ROR1 fusion protein Ag14586 相同性解析による交差性が予測される生物種 |
Full Name | receptor tyrosine kinase-like orphan receptor 1 |
Calculated molecular weight | 937 aa, 104 kDa |
Observed molecular weight | 130 kDa |
GenBank accession number | BC006374 |
Gene Symbol | ROR1 |
Gene ID (NCBI) | 4919 |
RRID | AB_2882250 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q01973 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
ROR1 is a member of the RTK family of orphan receptors related to muscle-specific kinase and Trk neurotrophin receptors (PMID: 18546292). ROR1 is primarily expressed by neural crest cells during embryogenesis. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition (PMID: 26245996). The human ROR1 gene encodes a 937 amino acid protein with an Ig-like domain, a cysteine-rich domain, a kringle domain, a tyrosine kinase domain, and a proline-rich domain. The calculated molecular weight of ROR1 is 104 kDa, but ROR1 has multiple N-glycosylation sites that generate post-translationally modified ROR1 at 130 kDa (PMID: 24752542).