Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
67006-1-PBS targets RRM2 in WB, IHC, IF/ICC, IP, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | RRM2 fusion protein Ag28664 相同性解析による交差性が予測される生物種 |
| Full Name | ribonucleotide reductase M2 polypeptide |
| Calculated molecular weight | 389 aa, 45 kDa |
| Observed molecular weight | 45 kDa |
| GenBank accession number | BC030154 |
| Gene Symbol | RRM2 |
| Gene ID (NCBI) | 6241 |
| RRID | AB_2882323 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P31350 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, a rate-limiting step in the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit [PMID:3894352].