RYR1 Monoclonal antibody, PBS Only
RYR1 Monoclonal Antibody for IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse
Applications
IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1B4E12
Cat no : 66539-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66539-1-PBS targets RYR1 in IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
Tested Reactivity | Human, Mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | RYR1 fusion protein Ag25120 相同性解析による交差性が予測される生物種 |
Full Name | ryanodine receptor 1 (skeletal) |
Calculated molecular weight | 565 kDa |
GenBank accession number | NM_000540 |
Gene symbol | RYR1 |
Gene ID (NCBI) | 6261 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. The transmembrane region of RyR1 is comprised of two domains including the pseudo voltage sensor domain and the pore-forming domain (PMID: 27855725). Dominant RyR1 mutations are the leading cause of MH. Studies on the Ca2+ conducting properties of RyR1 channels containing Malignant hyperthermia mutations expressed in myotubes.