SERBP1 Polyclonal antibody

SERBP1 Polyclonal Antibody for WB, IHC, IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, ELISA

Conjugate

Unconjugated

Cat no : 10729-1-AP

Synonyms

PAIRBP1, PAI1 RNA-binding protein 1, PAI RBP1, HABP4L, CHD3IP


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Tested Applications

Positive WB detected inmouse testis tissue
Positive IHC detected inhuman lung cancer tissue, human colon cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inU2OS cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 2 publications below

Product Information

10729-1-AP targets SERBP1 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SERBP1 fusion protein Ag1045 相同性解析による交差性が予測される生物種
Full Name SERPINE1 mRNA binding protein 1
Calculated molecular weight 45 kDa
Observed molecular weight 55 kDa
GenBank accession numberBC008045
Gene symbol SERBP1
Gene ID (NCBI) 26135
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

The plasminogen activator system (PA) plays an important role in invasion and metastasis of solid tumors. The PA Inhibitor type 1 (PAI-1) is the main physiologic regulator of plasminogen activation. PAI-RBP1 (PAI-1 mRNA Binding Protein 1, also named SERBP1), is an RNA-binding protein containing an RG-rich domain and an RGG box domain that might be methylated by protein arginine N-methyltransferases (PRMTs). SERBP1 was identified as an interacting partner of a Tudor domain containing protein TDRD3, and can localize to cytoplasmic stress granules (SGs).

Protocols

Product Specific Protocols
WB protocol for SERBP1 antibody 10729-1-APDownload protocol
IHC protocol for SERBP1 antibody 10729-1-APDownload protocol
IF protocol for SERBP1 antibody 10729-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle

Cell Rep

Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

Authors - Tao Yang
humanWB

J Clin Endocrinol Metab

The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.

Authors - Miao Li
humanWB

Front Genet

Identification of immune signatures in Parkinson's disease based on co-expression networks

Authors - Xiaolin Dong