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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

SFRP5 Polyclonal antibody, PBS Only

SFRP5 Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 19177-1-PBS

Synonyms

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human thyroid cancer tissue using SFRP5 Polyclonal antibody (19177-1-AP)

    IHC staining of human thyroid cancer using 19177-1-AP (same clone as 19177-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 19177-1-AP (SFRP5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19177-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human cervical cancer tissue using SFRP5 Polyclonal antibody (19177-1-AP)

    IHC staining of human cervical cancer using 19177-1-AP (same clone as 19177-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 19177-1-AP (SFRP5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19177-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human cervical cancer tissue using SFRP5 Polyclonal antibody (19177-1-AP)

    IHC staining of human cervical cancer using 19177-1-AP (same clone as 19177-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 19177-1-AP (SFRP5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19177-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

19177-1-PBS targets SFRP5 in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SFRP5 fusion protein Ag5715 相同性解析による交差性が予測される生物種
Full Name secreted frizzled-related protein 5
Calculated molecular weight 36 kDa
GenBank accession numberBC050435
Gene symbol SFRP5
Gene ID (NCBI) 6425
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes. SFRP5 is secreted by adipocytes and that it controls the micro-environment of white adipose tissue under conditions of metabolic stress (PMID: 20558665). SFRP5 gene consists of 317 amino acid residues and 3 coding exons and maps to chromosome 10q24.1 in humans. SFRP5 was initially found to be highly expressed in retinal pigment epithelium cells and moderately expressed in the pancreas. SFRP5 is involved in the pathological process of obesity, insulin resistance, dyslipidemia, inflammation, and fibrosis and is associated with obesity, T2D, and ASCVD (PMID: 31199714, PMID: 32004418).